Synthesis and Biological Evaluations of Click-Generated Nitrogen Mustards.

@article{Bons2015SynthesisAB,
  title={Synthesis and Biological Evaluations of Click-Generated Nitrogen Mustards.},
  author={Benjamin Bo{\"e}ns and T. S. Ouk and Yves Champavier and Rachida Zerrouki},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2015},
  volume={34 7},
  pages={500-14}
}
This paper describes the synthesis of new click-generated nitrogen mustards and their biological evaluation. By using the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, we managed to synthesize eight new nitrogen mustards. This strategy paves the way for the synthesis of a new family of nitrogen mustard, with an important structural… CONTINUE READING