Synthesis and Biological Evaluation of Kojyl Thioether Derivatives as Tyrosinase Inhibitors

  title={Synthesis and Biological Evaluation of Kojyl Thioether Derivatives as Tyrosinase Inhibitors},
  author={Ho Sik Rho and Heung Soo Baek and Soo Mi Ahn and Myung Kyoo Kim and Amal Kumar Ghimeray and Dong Ha Cho and Jae Sung Hwang},
  journal={Bulletin of The Korean Chemical Society},
  • H. RhoH. Baek J. Hwang
  • Published 20 August 2010
  • Chemistry
  • Bulletin of The Korean Chemical Society
) is well known depigmenting agent that is used to reduce melanin content by inhibition of tyrosinase. Although hydroquinone exhibits highly potent depigmenting activity, its application in cosmetics isrestricted because of its severe side effects such as melanocyte destruction, irritative dermatitis, and contact dermatitis. To over-come this disadvantage, its glycoside derivative, arbutin 

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