Synthesis and Biological Evaluation of 2- and 7-Substituted 9-Deazaadenosine Analogues

@article{Liu2005SynthesisAB,
  title={Synthesis and Biological Evaluation of 2- and 7-Substituted 9-Deazaadenosine Analogues},
  author={Mao-Chin Liu and M. Luo and D. E. Mozdziesz and A. Sartorelli},
  journal={Nucleosides, Nucleotides & Nucleic Acids},
  year={2005},
  volume={24},
  pages={45 - 62}
}
A series of 2-halogen and 7-alkyl substituted analogues of 9-deazaadenosine and 2′-deoxy-9-deazaadenosine was synthesized by new efficient methodology involving transformation of corresponding 9-deazaguanosine and 2′-deoxyguanosine, which in turn were synthesized by direct C-glycosylation of 1-benzyl-9-deazaguanine with 1-O -acetyl-2,3,5-tri-O -benzoyl-d-ribofuranose and methyl 2-deoxy-3,5-di-O -(p -toluoyl)-d-ribofuranoside, respectively. Deoxychlorination of C6 and diazotization/chloro- or… Expand
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