Synthesis and Biological Evaluation 6-chloro-2-substitued-1-[2-(1h- Tetrazol-5-yl)-biphenyl-4-ylmethyl]-1h-benzoimidazol-5-ylamine Antihypertensive Agents

Abstract

A series of methyl 6-Chloro-2-Substitued-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-5-ylamine were successfully synthesized. Benzimidazoles were prepared by condensation of 4-chloro-o-phenylenediamine with substituted aryl, aldehyde condensation with biphenyl tetrazole group and reduction stannous chloride dihydrate. An insertion… (More)

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