• Medicine
  • Published 2015

Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents

@inproceedings{Rayama2015SynthesisAB,
  title={Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents},
  author={Parsharamulu Rayama and Jaya Shree Anireddya and Naveen Polkama and Tejeswara Rao Allakaa and Kalyani Chepurib and Mukharjee Nadendlac},
  year={2015}
}
A series of acyl hydrazone derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid have been synthesized and screened for in vivo anti inflammatory, analgesic and in vitro anti cancer activities. The key intermediate N-acylhydrazine is prepared in good yield from NSAID oxaprozin, was coupled with a variety of aromatic aldehydes under conventional as well as microwave irradiation conditions. The microwave approach utilized solvent free condition, required short time and resulted in very… CONTINUE READING

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