Synthesis and Biodistribution of a New 99mTc‐oxo Complex with Deoxyglucose Dithiocarbamate for Tumor Imaging

  title={Synthesis and Biodistribution of a New 99mTc‐oxo Complex with Deoxyglucose Dithiocarbamate for Tumor Imaging},
  author={Xiao Lin and Zhong-hui Jin and Jialei Ren and Yan Pang and Weifang Zhang and Jinfeng Huo and Xuebin Wang and Junbo Zhang and Yan-yan Zhang},
  journal={Chemical Biology \& Drug Design},
The deoxyglucose dithiocarbamate (DGDTC) was radiolabeled with 99mTc(V)‐glucoheptonate (GH), for the potential use as radiopharmaceuticals for tumor imaging. For labeling, 99mTcO‐DGDTC was prepared by ligand‐exchange reaction with 99mTc‐GH. The radiochemical purity of the 99mTcO‐DGDTC complex was over 90% by thin‐layer chromatography and high‐performance liquid chromatography, without any notable decomposition at room temperature over a period of 6 h. Its partition coefficient indicated that it… 
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