Synthesis and Biodistribution of a New 99mTc‐oxo Complex with Deoxyglucose Dithiocarbamate for Tumor Imaging

@article{Lin2012SynthesisAB,
  title={Synthesis and Biodistribution of a New 99mTc‐oxo Complex with Deoxyglucose Dithiocarbamate for Tumor Imaging},
  author={Xiao Lin and Zhong-hui Jin and Jialei Ren and Yan Pang and Weifang Zhang and Jinfeng Huo and Xuebin Wang and Junbo Zhang and Yan-yan Zhang},
  journal={Chemical Biology \& Drug Design},
  year={2012},
  volume={79}
}
The deoxyglucose dithiocarbamate (DGDTC) was radiolabeled with 99mTc(V)‐glucoheptonate (GH), for the potential use as radiopharmaceuticals for tumor imaging. For labeling, 99mTcO‐DGDTC was prepared by ligand‐exchange reaction with 99mTc‐GH. The radiochemical purity of the 99mTcO‐DGDTC complex was over 90% by thin‐layer chromatography and high‐performance liquid chromatography, without any notable decomposition at room temperature over a period of 6 h. Its partition coefficient indicated that it… 
Synthesis and biodistribution of novel 99mTc labeled 4-nitroimidazole dithiocarbamate complexes as potential agents to target tumor hypoxia
TLDR
Among them, 99mTcO-N4IPDTC had the advantages of higher tumor uptake, and higher tumor/blood and tumor/muscle ratios.
99mTc labelled complexes with secnidazole xanthate: Synthesis and evaluation as potential radiotracers to target tumor hypoxia.
Synthesis and biodistribution of novel 99mTcN complexes of glucose dithiocarbamate as potential probes for tumor imaging
TLDR
The single-photon emission computed tomography (SPECT) image studies of 99mTcN-3b showed obvious radioactive uptake in the tumor region and the tumor-to-non-target ratio was high, suggesting that it could be regarded as a promising tumor imaging agent.
Novel 99mTc labelled complexes with 2-nitroimidazole isocyanide: design, synthesis and evaluation as potential tumor hypoxia imaging agents.
TLDR
Among them, 99mTc-2c exhibited the highest tumor uptake, tumor/blood and tumor/muscle ratios at 2 h post-injection, and single photon emission computed tomography (SPECT) imaging studies indicated clear accumulation in tumors, suggesting that 99m Tc- 2c was a promising candidate for hypoxia imaging.
Synthesis and biological evaluation of novel 99mTc-oxo and 99mTc-nitrido complexes with phenylalanine dithiocarbamate for tumor imaging
TLDR
In this study, phenylalanine dithiocarbamate ligand was successfully synthesized and then radiolabeled with [99mTcO]3+ core and [99MTc≡N]2+ core to produce 99mT cO–PHEDTC and 99m TcN–PH EDTC, respectively, which showed they were hydrophilic and had good stability.
Synthesis and preliminary evaluation of a 99mTc labelled deoxyglucose complex {[99mTc]DTPA-bis(DG)} as a potential SPECT based probe for tumor imaging
TLDR
The results suggested that this 1-D-deoxyglucose conjugate would be a promising candidate for cancer targeted imaging.
Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor
TLDR
99mTc-EDTADG showed good in vitro stability and single photon emission computed tomography imaging clearly visualized the tumor, suggesting it could be considered as a potential agent for tumor imaging.
Macrocyclic triamine derived glucose analogues for 99mTc(CO)3 labeling: synthesis and biological evaluation as potential tumor‐imaging agents
[99mTc(CO)3(H2O)3]+ has attracted great attention among 99mTc‐labeling techniques, due to its ease of preparation, readily substituted water molecules of the precursor fac‐[99mTc(CO)3(H2O)3]+ by a
...
...

References

SHOWING 1-10 OF 19 REFERENCES
Synthesis and evaluation of a technetium-99m-labeled diethylenetriaminepentaacetate-deoxyglucose complex ([99mTc]-DTPA-DG) as a potential imaging modality for tumors.
Assessment of therapeutic tumor response using 99mtc-ethylenedicysteine-glucosamine.
TLDR
99mTc-EC-DG is involved in cell nuclei activity and could assess the therapeutic tumor response and the efficacy of paclitaxel and cisplatin treatment in rodent models could be assessed using tumor/muscle ratios.
Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase.
TLDR
The cellular uptake of all 99mTc-complexes into HT-29 colon carcinoma cells via Glut1 was generally low and unspecific independent of the position at the hexose ring, the chelating systems, or the overall charge of the corresponding metal complexes.
Carbohydrate conjugates for molecular imaging and radiotherapy: 99mTc(I) and 186Re(I) tricarbonyl complexes of N-(2'-Hydroxybenzyl)-2-amino-2-deoxy-D-glucose.
An approach to a new class of potential radiopharmaceuticals is demonstrated by the labeling of a glucosamine derivative with the tricarbonyls of 99mTc and 186Re. The proligand HL2
Evolution of Tc-99m in diagnostic radiopharmaceuticals.
TLDR
The evolution of 99mTc dating back to its discovery, the development of 99Mo/99m Tc generators, and the efforts to exploit the diverse chemistry of the element to explore a spectrum of compounds for diagnostic imaging, planar, and single photon emission computed tomography are reviewed.
Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium.
TLDR
It appears that 99mTc-glucarate and 3H-deoxyglucose demarcate different points in the spectrum of myocardial injury.
...
...