Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review
@article{Thombre2005SynthesisAB, title={Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review}, author={Sunita M. Thombre and Bhimrao D. Sarwade}, journal={Journal of Macromolecular Science, Part A}, year={2005}, volume={42}, pages={1299 - 1315} }
Poly(aspartic acid) (PAA) being biodegradable is suitable for various industrial medical and agricultural applications to replace many non‐biodegradable polymers in use. Poly(aspartic acid) can be synthesized by different methods with and without catalyst in different forms such as polysuccinimide, either hydrolyzed to acid or salt. The polymer of (aspartic acid) is present in different forms such as α,β and L, D isomers. The conformational analysis of poly(aspartic acid) was done by various…
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References
SHOWING 1-10 OF 117 REFERENCES
Poly(aspartic acid): Synthesis, biodegradation, and current applications
- Biology
- 1997
This review of current investigative and patent literature describes methods of synthesis, biodegradative studies, and important current and potential applications of both poly(aspartic acid) homopolymers and copolymers.
Biodegradation of thermally synthesized polyaspartate
- Engineering
- 1994
Polyaspartate synthesized using thermal methods (thermal polyaspartate; TPA) has been shown to have dispersant and crystallization inhibition activities. These activities suggest that the polymer may…
Synthesis of uniform poly(aspartic acids)
- Chemistry, Biology
- 1993
A qualitative correlation was demonstrated between the retention times from gel-permeation chromatographic analysis and the 1H NMR method used to estimate the polymer chain length.
Biodegradation of copoly(L‐aspartic acid/L‐glutamic acid) in vitro
- Materials ScienceBiopolymers
- 1990
The nature of side chains are important to the rate of degradation by papain and it was controlled by the comonomer composition as well as the sequential distribution of comonomers in the copolymer chains.
Synthesis and characterization of biodegradable poly(L‐aspartic acid‐co‐PEG)
- Chemistry, Materials Science
- 1998
The melt polycondensation reaction of the prepolymer prepared from N-(benzyloxycarbonyl)-L-aspartic acid anhydride (N-CBz-L-aspartic acid anhydride) and low molecular weight poly(ethylene glycol)…
Relationships between Structure and Properties of Poly(aspartic acid)s
- Materials Science, Biology
- 1998
The result of repetitive biodegradability analyses for poly-aspartic acid suggested the complete biodegradation is possible and the type of amide linkage affected the calcium ion chelating ability.
Synthesis of poly(succinimide) by bulk polycondensation of L‐aspartic acid with an acid catalyst
- Chemistry
- 2000
The bulk polycondensation of L-aspartic acid (ASP) with an acid catalyst under batch and continuous conditions was established as a preparative method for producing poly(succinimide) (PSI). Although…
In vitro degradation of polylactide and poly(lactide-co-glycolide) microspheres
- Materials Science
- 1991
Polyactide (PLA) and poly(lactide-co-glycolide) (PLGA) were prepared by bulk ring-opening polymerization of lactide or lactide/glycolide using stannous octoate as initiator. PLA and PLGA microspheres…
Copolymerization and Degradation of Poly(lactic acid-co-lysine)
- Materials Science
- 1995
Poly(lactic acid-co-lysine) has been synthesized and the side-chain amino groups of the lysine residues have been modified with an RGD (arginine-glycine-aspartic acid) cell adhesion promoting…
A review of biodegradable polymers: uses, current developments in the synthesis and characterization of biodegradable polyesters, blends of biodegradable polymers and recent advances in biodegradation studies
- Engineering, Materials Science
- 1998
This review considers the uses of biodegradable polymers in terms of their relevance within current plastic waste management of packaging materials, biomedical applications and other uses; research…