Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review

@article{Thombre2005SynthesisAB,
  title={Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review},
  author={Sunita M. Thombre and Bhimrao D. Sarwade},
  journal={Journal of Macromolecular Science, Part A},
  year={2005},
  volume={42},
  pages={1299 - 1315}
}
Poly(aspartic acid) (PAA) being biodegradable is suitable for various industrial medical and agricultural applications to replace many non‐biodegradable polymers in use. Poly(aspartic acid) can be synthesized by different methods with and without catalyst in different forms such as polysuccinimide, either hydrolyzed to acid or salt. The polymer of (aspartic acid) is present in different forms such as α,β and L, D isomers. The conformational analysis of poly(aspartic acid) was done by various… 
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118 Citations

Polysuccinimide and its derivatives: Degradable and water soluble polymers (review)
A Novel Bio-based Polyaspartic Acid Copolymer: Synthesis, Structure and Performance of Degradation
A novel bio-based polyaspartic acid copolymer, as a multifunctional polymer was fabricated via in-site melting polymerization method using l-aspartic acid, γ-aminobutyric acid, l-phenylalanine and…
Properties of Copolymers of Aspartic Acid and Aliphatic Dicarboxylic Acids Prepared by Reactive Extrusion
Aspartic acid is prepared chemically or by the fermentation of carbohydrates. Currently, low mo- lecular weight polyaspartic acids are prepared commer- cially by heating aspartic acid at high…
Kinetic analysis of solid-phase polycondensation of aspartic acid
327 Polycondensation of amino acids is the subject of a multitude of studies. Compounds of this class are important both for chemical engineering, e.g., production of polyamides, and for chemical…
Poly(aspartic acid) (PAA) hydrolases and PAA biodegradation: current knowledge and impact on applications
  • T. Hiraishi
  • Biology, Engineering
    Applied Microbiology and Biotechnology
  • 2015
TLDR
The novel reactivity of PAA hydrolase-1 makes it a good candidate for a biocatalyst in β-peptide synthesis, and functionally related enzymes, such as poly(R-3-hydroxybutyrate) depolymerases and β-aminopeptidases, are compared to PAAHydrolases.
Synthesis of poly(aspartimide)-based bio-glycoconjugates.
1H and 13C NMR Analysis of Poly(succinimide) Prepared by Microwave-Enhanced Polycondensation of L-Aspartic Acid
Poly(succinimide) (PSI) is a polymer of aspartic acid with interesting properties and numerous possible uses. Application areas include agriculture, cleaning agents, metallurgy, the building…
Polyamide/Poly(Amino Acid) Polymers for Drug Delivery
TLDR
This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility and a thorough discussion on anticancer agents incorporated into poly(Amino Acid) micellar systems that are under clinical evaluation is included.
An injectable and biodegradable hydrogel based on poly(α,β-aspartic acid) derivatives for localized drug delivery.
TLDR
An injectable hydrogel via hydrazone cross-linking was prepared under mild conditions without addition of cross-linker or catalyst and the polymeric hydrogels showed good biocompatibility.
Aspartic and glutamic acids polymers: preparation and applications in medicinal chemistry and pharmaceutics
The methods of the fabrication of polymers based on aspartic and glutamic acids as monomers are reviewed. The methods are perspective from the viewpoint of green chemistry and economics. Actual…
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