Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review

  title={Synthesis and Biodegradability of Polyaspartic Acid: A Critical Review},
  author={Sunita M. Thombre and Bhimrao D. Sarwade},
  journal={Journal of Macromolecular Science, Part A},
  pages={1299 - 1315}
Poly(aspartic acid) (PAA) being biodegradable is suitable for various industrial medical and agricultural applications to replace many non‐biodegradable polymers in use. Poly(aspartic acid) can be synthesized by different methods with and without catalyst in different forms such as polysuccinimide, either hydrolyzed to acid or salt. The polymer of (aspartic acid) is present in different forms such as α,β and L, D isomers. The conformational analysis of poly(aspartic acid) was done by various… 
A Novel Bio-based Polyaspartic Acid Copolymer: Synthesis, Structure and Performance of Degradation
A novel bio-based polyaspartic acid copolymer, as a multifunctional polymer was fabricated via in-site melting polymerization method using l-aspartic acid, γ-aminobutyric acid, l-phenylalanine and
Properties of Copolymers of Aspartic Acid and Aliphatic Dicarboxylic Acids Prepared by Reactive Extrusion
Aspartic acid is prepared chemically or by the fermentation of carbohydrates. Currently, low mo- lecular weight polyaspartic acids are prepared commer- cially by heating aspartic acid at high
Synthesis and characterization of zwitterionic peptides derived from natural amino acids and their resistance to protein adsorption
Various functional groups can be easily introduced onto the poly(α,β-L-aspartic acid) by using different reagents to open the succinimide ring in polysuccinimide (PSI). In this work, two natural
Kinetic analysis of solid-phase polycondensation of aspartic acid
327 Polycondensation of amino acids is the subject of a multitude of studies. Compounds of this class are important both for chemical engineering, e.g., production of polyamides, and for chemical
Poly(aspartic acid) (PAA) hydrolases and PAA biodegradation: current knowledge and impact on applications
  • T. Hiraishi
  • Biology, Engineering
    Applied Microbiology and Biotechnology
  • 2015
The novel reactivity of PAA hydrolase-1 makes it a good candidate for a biocatalyst in β-peptide synthesis, and functionally related enzymes, such as poly(R-3-hydroxybutyrate) depolymerases and β-aminopeptidases, are compared to PAAHydrolases.
Poly(aspartate) hydrolases: biochemical properties and applications
The enzyme-catalyzed synthesis of poly(α-ethyl β-aspartate), which is composed of only β-linkages and belongs to β-peptides, is reported here, using the unique substrate specificity of the enzyme from Pedobacter sp.
Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight
The preliminary data indicate the MW dependence of bioactivity of l-aspartic acid-derived polymers designed as drug carriers and biocompatible materials is dependent on cell type and polymer MW.
1H and 13C NMR Analysis of Poly(succinimide) Prepared by Microwave-Enhanced Polycondensation of L-Aspartic Acid
Poly(succinimide) (PSI) is a polymer of aspartic acid with interesting properties and numerous possible uses. Application areas include agriculture, cleaning agents, metallurgy, the building


Poly(aspartic acid): Synthesis, biodegradation, and current applications
This review of current investigative and patent literature describes methods of synthesis, biodegradative studies, and important current and potential applications of both poly(aspartic acid) homopolymers and copolymers.
Biodegradation of thermally synthesized polyaspartate
Polyaspartate synthesized using thermal methods (thermal polyaspartate; TPA) has been shown to have dispersant and crystallization inhibition activities. These activities suggest that the polymer may
Synthesis of uniform poly(aspartic acids)
A qualitative correlation was demonstrated between the retention times from gel-permeation chromatographic analysis and the 1H NMR method used to estimate the polymer chain length.
Biodegradation of copoly(L‐aspartic acid/L‐glutamic acid) in vitro
The nature of side chains are important to the rate of degradation by papain and it was controlled by the comonomer composition as well as the sequential distribution of comonomers in the copolymer chains.
Synthesis and characterization of biodegradable poly(L‐aspartic acid‐co‐PEG)
The melt polycondensation reaction of the prepolymer prepared from N-(benzyloxycarbonyl)-L-aspartic acid anhydride (N-CBz-L-aspartic acid anhydride) and low molecular weight poly(ethylene glycol)
Preparation and characterization of dodecylamine-modified poly(aspartic acid) as a biodegradable water-soluble polymeric material
Sodium DDA-modified poly(aspartate) (DDA-PASP-Na) was obtained in high yield by hydrolysis using NaOH solution and exhibited biodegradability and a high MnO2-dispersion property.
Relationships between Structure and Properties of Poly(aspartic acid)s
The result of repetitive biodegradability analyses for poly-aspartic acid suggested the complete biodegradation is possible and the type of amide linkage affected the calcium ion chelating ability.
Synthesis of poly(succinimide) by bulk polycondensation of L‐aspartic acid with an acid catalyst
The bulk polycondensation of L-aspartic acid (ASP) with an acid catalyst under batch and continuous conditions was established as a preparative method for producing poly(succinimide) (PSI). Although
In vitro degradation of polylactide and poly(lactide-co-glycolide) microspheres
Polyactide (PLA) and poly(lactide-co-glycolide) (PLGA) were prepared by bulk ring-opening polymerization of lactide or lactide/glycolide using stannous octoate as initiator. PLA and PLGA microspheres
Copolymerization and Degradation of Poly(lactic acid-co-lysine)
Poly(lactic acid-co-lysine) has been synthesized and the side-chain amino groups of the lysine residues have been modified with an RGD (arginine-glycine-aspartic acid) cell adhesion promoting