Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains.

Abstract

The effect on the bioactivity of antibacterial sulfonamide drugs against malaria and tuberculosis via an increase of the lipid solubility groups by condensation with a reduced chalcone was investigated. Sulfonamide derivatives (8a-8d) were obtained via a 1,3-diarylpropane scaffold, prepared by reduction of the relevant chalcones, followed by the addition of… (More)
DOI: 10.1021/acs.jnatprod.7b00570

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