Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues

  title={Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues},
  author={Eva Heřm{\'a}nkov{\'a}-Vavř{\'i}kov{\'a} and Alena Křenkov{\'a} and Lucie Petr{\'a}skov{\'a} and Christopher Steven Chambers and Jakub Z{\'a}pal and Marek Kuzma and Kateřina Valentov{\'a} and Vladim{\'i}r Křen},
  booktitle={International journal of molecular sciences},
Isoquercitrin, (IQ, quercetin-3-O-β-d-glucopyranoside) is known for strong chemoprotectant activities. Acylation of flavonoid glucosides with carboxylic acids containing an aromatic ring brings entirely new properties to these compounds. Here, we describe the chemical and enzymatic synthesis of a series of IQ derivatives at the C-6″. IQ benzoate, phenylacetate, phenylpropanoate and cinnamate were prepared from respective vinyl esters using Novozym 435 (Lipase B from Candida antarctica… CONTINUE READING
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