Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues

Abstract

Two new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and indole units were both substituted by 7-azaindole moieties or one indole unit was replaced by a 6-azaindole portion, were efficiently synthesized. Compounds belonging to both series inhibited the growth of HCT-116 colorectal cancer cells… (More)
DOI: 10.3390/md13010460

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@inproceedings{Carbone2015SynthesisAA, title={Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues}, author={Anna Carbone and Barbara Parrino and Gloria Di Vita and Alessandro Attanzio and Virginia Span{\`o} and Alessandra Montalbano and Paola Barraja and Luisa Tesoriere and Maria Antonia Livrea and Patrizia Diana and Girolamo Cirrincione}, booktitle={Marine drugs}, year={2015} }