Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

@inproceedings{Barbuceanu2014SynthesisAA,
  title={Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties},
  author={Stefania-Felicia Barbuceanu and Diana Carolina Ilies and Gabriel Saramet and Valentina Uivarosi and Constantin Drăghici and Valeria Radulescu},
  booktitle={International journal of molecular sciences},
  year={2014}
}
In the present investigation, new hydrazinecarbothioamides 4-6 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X=H, Cl, Br) 1-3 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hydroxide to obtain 1,2,4-triazole-3-thione derivatives 7-9. The reaction of 7-9 with α-halogenated ketones, in basic… CONTINUE READING