Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides

@inproceedings{Zi2015SynthesisAA,
  title={Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides},
  author={Cheng-Ting Zi and Gen-Tao Li and Yan Li and Jun Zhou and Zhong-tao Ding and Z Jiang and Jiangmiao Hu},
  booktitle={Natural Products and Bioprospecting},
  year={2015}
}
A series of novel 4β-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click reaction. Evaluation of cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assay shows that most of these compounds show weak cytotoxicity. It was observed that compound 16 shows the highest activity… CONTINUE READING