Synthesis and Anti-microbial studies of ( E )-4-Oxoalk-2-enoic acids

E)-4-Oxonon-2-enoic acid 1a is a fatty acid, isolated from the mycelium of Streptomyces olevaceus. Owing to its significant activity against various Gram-positive and Gram-negative strains and particularly Staphylococcus aureus ATCC 11632; it is an attractive target for structure-activity relationship. We report herein a straightforward synthesis of (E)-4… CONTINUE READING