Synthesis and Anti-Tumor Activity of Proanthocyanidins

@inproceedings{Makabe2013SynthesisAA,
  title={Synthesis and Anti-Tumor Activity of Proanthocyanidins},
  author={H. Makabe},
  year={2013}
}
Since Konings and co-workers reported moderate cytotoxicity of proanthocyanidins to human tumour cell lines in 1994 [1], more than 50 papers have been reported. However, in most of cases, evaluation of antitumor activity was investigated using the mixture of proanthocyanidins such as “grape seeds extract”. Thus the numbers of report of systematic structural activity relationship study (SAR) of proanthocyanidins against tumor cell lines are still limited. To solve this problem, synthesis of… Expand
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