Synthesis and Analgesic Activity of [b]-Annelated 4-Quinolones

  title={Synthesis and Analgesic Activity of [b]-Annelated 4-Quinolones},
  author={Antoaneta Boteva and I. V. Fefilova and Galina A Triandafilova and Vera V. Maslova and Sergey Yu. Solodnikov and Olga P. Krasnykh},
  journal={Pharmaceutical Chemistry Journal},
  pages={616 - 619}
Considering the side effects of existing drugs used for pain relief, the search for new analgesics with high efficacy and safety remains relevant. Aseries of imidazopyrrolo[3,4-b]quinoline-5,11-diones and pyrimidopyrrolo[3,4-b]quinoline-6,12-diones II were synthesized, whose analgesic activity at a dose of 0.05 mmol/kg was studied in the hotplate test in rats after i.p. administration. One compound was found with analgesic activity comparable to that of reference compound diclofenac sodium… 
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An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs
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