Synthesis and Analgesic Activity of [b]-Annelated 4-Quinolones

@article{Boteva2019SynthesisAA,
  title={Synthesis and Analgesic Activity of [b]-Annelated 4-Quinolones},
  author={Antoaneta Boteva and I. V. Fefilova and Galina A Triandafilova and Vera V. Maslova and Sergey Yu. Solodnikov and Olga P. Krasnykh},
  journal={Pharmaceutical Chemistry Journal},
  year={2019},
  volume={53},
  pages={616 - 619}
}
Considering the side effects of existing drugs used for pain relief, the search for new analgesics with high efficacy and safety remains relevant. Aseries of imidazopyrrolo[3,4-b]quinoline-5,11-diones and pyrimidopyrrolo[3,4-b]quinoline-6,12-diones II were synthesized, whose analgesic activity at a dose of 0.05 mmol/kg was studied in the hotplate test in rats after i.p. administration. One compound was found with analgesic activity comparable to that of reference compound diclofenac sodium… 
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Antimicrobial and antiproliferative activity studies of some new quinoline-3-carbaldehyde hydrazone derivatives.

References

SHOWING 1-10 OF 12 REFERENCES
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs
TLDR
This review will provide an educational update on the current evidence of the efficacy and adverse effects of NSAIDs, and an algorithm is proposed which delineates a general decision-making tree to select the most appropriate analgesic for an individual patient based on the evidence reviewed.
Side effects of commonly prescribed analgesic medications.
Methyl 3-aroyl-4-oxo-1,4-dihydroquinoline-2-carboxylates: synthesis and molecular and crystal structures
Thermal decarbonylation of methyl 1-aryl-3-(het)aroyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates afforded 8-substituted methyl 3-(het)aroyl-4-oxo-1,4-dihydroquinoline-2-carboxylates. X-ray…
Protein kinase C in pain: involvement of multiple isoforms.
The epidemiology and economic consequences of pain.
Corrigendum: Magmatic record of India-Asia collision
TLDR
In Supplementary Figure 1a, the Linzizong volcanic rock samples ‘ 12LZ14-1’ and ‘12LZ13- 1’ should read ‘13LZ12-1-1@02” and ’13Lz14-2-1 @02’ respectively, and the correct figure appears below as Fig. 1.
Official J
  • Italian Pharmacol. Soc., 55(6), 578 – 589
  • 2007
Adverse cardiovascular effects of the coxibs.
Syropyatov, Doses of Drugs and Chemical Compounds for Rational Use [in Russian], Meditsina
  • Moscow
  • 1998
...
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