Synthesis and 1H and 13C nuclear magnetic resonance of 16-methylene-17 alpha-hydroxypregna-1,4,9(11)-triene-3,20-dione.

Abstract

A three-step synthesis of 16-methylene-17 alpha-hydroxypregna-1,4,9(11)- triene-3,20-dione, which has been previously obtained by microbial transformation, was achieved from 3 beta-hydroxy-16 alpha, 17-epoxy-16 beta-methyl-5 alpha-pregn-9(11)-en-20-one in an overall yield of 35%. All compounds involved in the process were characterized spectroscopically and their 13C NMR shielding effects are briefly discussed.

Cite this paper

@article{GarcaMartnez1993SynthesisA1, title={Synthesis and 1H and 13C nuclear magnetic resonance of 16-methylene-17 alpha-hydroxypregna-1,4,9(11)-triene-3,20-dione.}, author={Cirilo Garc{\'i}a-Mart{\'i}nez and Joaquin L. Reyes-L{\'o}pez and Pedro Joseph-Nathan}, journal={Steroids}, year={1993}, volume={58 9}, pages={396-9} }