Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.

@article{Cumpstey2011SynthesisA,
  title={Synthesis and $\alpha$-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.},
  author={I. Cumpstey and Clinton Ramstadius and K. Eszter Borbas and D. Alonzi and T. Butters},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2011},
  volume={21 18},
  pages={
          5219-23
        }
}
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the… Expand
4 Citations

References

SHOWING 1-10 OF 35 REFERENCES
Carbasugar-thioether pseudodisaccharides related to N-glycan biosynthesis.
Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent.
Synthesis and Biological Characterisation of Novel N‐Alkyl‐Deoxynojirimycin α‐Glucosidase Inhibitors
The action of bromoconduritol on ER glucosidase II.
...
1
2
3
4
...