Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.

Abstract

A bacteria-targeted MR contrast agent, Zn-1, consisting of two Zn-dipicolylamine (Zn-dpa) groups conjugated to a Gd(III) chelate has been synthesized and characterized. In vitro studies with S. aureus and E. coli show that Zn-1 exhibits a significant improvement in bacteria labeling efficiency vs. control. Studies with a structural analogue, Zn-2, indicate that removal of one Zn-dpa moiety dramatically reduces the agent's affinity for bacteria. The ability of Zn-1 to significantly reduce the T1 of labeled vs. unlabeled bacteria, resulting in enhanced MR image contrast, demonstrates its potential for visualizing bacterial infections in vivo.

Cite this paper

@article{Matosziuk2012SynthesisCA, title={Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.}, author={Lauren M Matosziuk and Allison S. Harney and Keith W Macrenaris and Thomas J Meade}, journal={European journal of inorganic chemistry}, year={2012}, volume={2012 12}, pages={2099-2107} }