Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides.

Abstract

BACKGROUND Sorafenib is an important VEGFR2/KDR inhibitor which is widely used for the treatment of cancer. OBJECTIVE In this paper, two series of sorafenib analogues N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4- phenylpicolinamides(13a-k) and N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-5-phenylpicolinamides (14a-k) were designed and synthesized. METHODS Their… (More)
DOI: 10.2174/1573406413666161117123203

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Cite this paper

@article{Wang2017SynthesisBE, title={Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides.}, author={Min Wang and Chunjiang Wu and Shan Xu and Yan Zhu and Wei Li and Pengwu Zheng and Wufu Zhu}, journal={Medicinal chemistry (Shariqah (United Arab Emirates))}, year={2017}, volume={13 2}, pages={176-185} }