Synthesis, Antiviral and Antibacterial Activities of Isatin Mannich Bases


HIV is the most significant risk factor for many opportunistic infections like tuberculosis, hepatitis, bacterial infections etc. We designed an isatin lead compound as a novel non-nucleoside reverse transcriptase inhibitor with broad-spectrum chemotherapeutic properties for the effective treatment of AIDS and AIDS-related opportunistic infections. Compound 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[[N4-[3′-(4′-amino-5′-trimethoxybenzyl pyrimidin-2′-yl)imino-1′-(5-chloroisatinyl)[methyl]-N1-piperazinyl]-3-quinoline carboxylic acid (14) emerged as the most potent broad-spectrum chemotherapeutic agent active against HIV, HCV, M. tuberculosis and various pathogenic bacteria.

DOI: 10.1007/s00044-005-0135-x

Cite this paper

@article{Sriram2005SynthesisAA, title={Synthesis, Antiviral and Antibacterial Activities of Isatin Mannich Bases}, author={Dharmarajan Sriram and Tanushree Ratan Bal and Perumal Yogeeswari}, journal={Medicinal Chemistry Research}, year={2005}, volume={14}, pages={211-228} }