Corpus ID: 2597921

Synthesis , Characterisation and Cytotoxicity Activity of Thiazole Substitution of Coumarin Derivatives ( Characterisation of Coumarin Derivatives )

  title={Synthesis , Characterisation and Cytotoxicity Activity of Thiazole Substitution of Coumarin Derivatives ( Characterisation of Coumarin Derivatives )},
  author={F. Rahman and Samina Khan Yusufzai and H. Osman and D. Mohamad},
Three types of coumarin derivatives were synthetised using the Knoevenagel condensation technique. All of these compounds have been characterised by the Fourier Transform Infrared (FTIR) and the Nuclear Magnetic Resonance (NMR) spectroscopy (H NMR, C NMR) to evaluate their chemical properties. The first step of synthesis involved preparing 3-acetylcoumarin 1 followed by the synthetisation of hydrazine thiosemicarbazide coumarin derivative 2 by treating thiosemicarbazide in the presence of a… Expand

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