Synthesis, transformation and biological evaluation of 2,3-secotriterpene acetylhydrazones and their derivatives.

@article{Grishko2013SynthesisTA,
  title={Synthesis, transformation and biological evaluation of 2,3-secotriterpene acetylhydrazones and their derivatives.},
  author={V. V. Grishko and I. A. Tolmacheva and N. V. Galaiko and Anastasia V Pereslavceva and L. Anikina and L. Volkova and B. Bachmetyev and P. Slepukhin},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={68},
  pages={
          203-11
        }
}
It has been previously shown that semi-synthetic A-secotriterpene acetylhydrazones of 1-cyano-28-methoxy-28-oxo-2,3-seco-2-norlup-20(29)-en-3-al and 1-cyano-2,3-seco-2-nor-19β,28-epoxy-18αH-olean-3-al (1, 2) inhibit the vesicular stomatitis virus (VSV) replication. To improve the antiviral activity against VSV, structural modifications of compounds 1 and 2 were performed, and new A-secoderivatives containing the acetylhydrazone fragment were obtained from betulonic acid and its methyl ester… Expand
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