Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.


Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H(2)O(2)/TFE in presence of MeReO(3) as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity… (More)
DOI: 10.1016/j.bmcl.2007.12.069


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