Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate benzyl triesters.

@article{Engels1977SynthesisSA,
  title={Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate benzyl triesters.},
  author={Joachim Engels and E. J. Schlaeger},
  journal={Journal of medicinal chemistry},
  year={1977},
  volume={20 7},
  pages={907-11}
}
A series of triesters of adenosine cyclic 3',5'-phosphate was synthesized by treatment of the free acid with various diazoalkanes (R=H, CH3, C6H5,0-NO2C6H4, p-NO2C6H4, p-CH3C6H4). The resulting diastereomeric mixtures were separated into their axial and equatorial components. Hydrolysis of the compounds was examined as well as photolysis of the photolabile o-nitrobenzyl ester. All compounds were then tested for their ability to activate the cAMP-dependent protein kinase and for their ability to… CONTINUE READING
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