Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)

@inproceedings{Li2018SynthesisSA,
  title={Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)},
  author={Kelin Li and Charles Kyriakos Vorkas and Ashutosh Chaudhry and Donielle L Bell and Richard A Willis and Alexander Y Rudensky and John D Altman and Michael S Glickman and Jeffrey Aub{\'e}},
  booktitle={PloS one},
  year={2018}
}
Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and are postulated to play a role in innate antibacterial immunity through production of cytokines and direct bacterial killing. MR1 tetramers, typically stabilized by the adduct of 5-amino-6-D-ribitylaminouracil (5-A-RU) and methylglyoxal (MeG), are… CONTINUE READING

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