Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers.

@article{Liu2007SynthesisSA,
  title={Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers.},
  author={Yanli Liu and Mathew K Shipton and Joseph Ryan and Eric D Kaufman and Stefan Franzen and Daniel L. Feldheim},
  journal={Analytical chemistry},
  year={2007},
  volume={79 6},
  pages={2221-9}
}
Gold nanoparticles have shown great promise as therapeutics, therapeutic delivery vectors, and intracellular imaging agents. For many biomedical applications, selective cell and nuclear targeting are desirable, and these remain a significant practical challenge in the use of nanoparticles in vivo. This challenge is being addressed by the incorporation of cell-targeting peptides or antibodies onto the nanoparticle surface, modifications that frequently compromise nanoparticle stability in high… CONTINUE READING

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