Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.

@article{Hindi2008SynthesisSA,
  title={Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.},
  author={Khadijah M. Hindi and Tammy J Siciliano and Semih Durmus and Matthew J. Panzner and Doug A. Medvetz and Dastigiri N Reddy and Lisa A Hogue and Christine E. Hovis and Julia K Hilliard and Rebekah J Mallet and Claire A. Tessier and Carolyn L. Cannon and Wiley J. Youngs},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 6},
  pages={1577-83}
}
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections. 

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