Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease.

@article{Shen1996SynthesisRP,
  title={Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease.},
  author={Xiao M Shen and Bin Xia and Monika Z Wrona and Glenn Dryhurst},
  journal={Chemical research in toxicology},
  year={1996},
  volume={9 7},
  pages={1117-26}
}
A very early event in the pathogenesis of idiopathic Parkinson's disease (PD) has been proposed to be an elevated translocation of L-cysteine (CySH) and/or glutathione (GSH) into pigmented dopaminergic cell bodies in the substantia nigra (SN) in which cytoplasmic dopamine (DA) is normally autoxidized to DA-o-quinone as the first step in a reaction leading to black neuromelanin polymer. Such an elevated influx of CySH and GSH would be expected to initially result in formation of 5-S… CONTINUE READING

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In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
In this investigation , however , it is demonstrated that 5-S - Glu - DA is rapidly metabolized in rat brain to 5-S - CyS - DA and 5-S-(N - acetylcysteinyl ) dopamine ( 5 ) in reactions mediated by gamma - glutamyl transpeptidase ( gamma - GT ) and cysteine conjugate N - acetyltransferase .
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