Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.


By seeking new stable boron-containing nucleoside derivatives, potential BNCT boron delivery agents, a novel synthetic approach was tested, aimed at a boron attachment via a single bond to an aliphatic carbon of sp(3) hybridization. The latter allowed successful modification of deoxycytidine in the reaction with 2-(iodomethyl)-4,4,5,5-tetramethyl-1,3,2… (More)
DOI: 10.1016/j.bmc.2014.06.014