Synthesis, purification and sample experiment for fluorescent pteridine-containing DNA: tools for studying DNA interactive systems

@article{Hawkins2007SynthesisPA,
  title={Synthesis, purification and sample experiment for fluorescent pteridine-containing DNA: tools for studying DNA interactive systems},
  author={Mary Ellen Hawkins},
  journal={Nature Protocols},
  year={2007},
  volume={2},
  pages={1013-1021}
}
Fluorescent nucleoside analogs provide a means to study DNA interactive systems through direct measurement of fluorescence properties. As integrated parts of DNA, these probes provide opportunities for monitoring subtle changes in DNA structure as it meets and reacts with other molecules. This protocol describes modifications to standard DNA synthesis to efficiently use smaller volumes of the probe phosphoramidite, purification of pteridine-containing sequences and a deprotection procedure… CONTINUE READING

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