Synthesis, processing, and secretion of the Marek's disease herpesvirus A antigen glycoprotein.

@article{Isfort1986SynthesisPA,
  title={Synthesis, processing, and secretion of the Marek's disease herpesvirus A antigen glycoprotein.},
  author={Robert J. Isfort and R A Stringer and Hsing Jien Kung and Leland F. Velicer},
  journal={Journal of virology},
  year={1986},
  volume={57 2},
  pages={464-74}
}
The 57,000- to 65,000-dalton (Da) Marek's disease herpesvirus A (MDHV-A) antigen glycoprotein (gp57-65) has a 47,000-Da unglycosylated precursor polypeptide (pr47), as determined by immunological detection after cell-free translation of infected-cell mRNA. Cleavage of its signal peptide yielded a 44,000-Da precursor polypeptide molecule (pr44), detected both in vivo after tunicamycin inhibition of glycosylation and in vitro after dog pancreas microsome processing of pr47. High-resolution pulse… CONTINUE READING