Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains.

Abstract

The elevated expression of LDL receptor on tumor cells provides one attractive approach for targeted drug delivery to tumor cells. Suitable antitumor compounds, however, need to be synthesized and developed which mimic the native cholesteryl esters (as major constituent of LDL) in chemical structure for targeted delivery to tumor cells through the over… (More)

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@article{Alanazi2003SynthesisPA, title={Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains.}, author={Fars Kaed Alanazi and Hengguang Li and David S Halpern and Svein \Oie and Daru Lu}, journal={International journal of pharmaceutics}, year={2003}, volume={255 1-2}, pages={189-97} }