Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes

@inproceedings{Mulvey2014SynthesisPA,
  title={Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes},
  author={Joseph Justin Mulvey and Evan N. Feinberg and Simone Alidori and Michael R McDevitt and Daniel A Heller and David A. Scheinberg},
  booktitle={International journal of nanomedicine},
  year={2014}
}
We aimed to create a more robust and more accessible standard for amine-modifying single-walled carbon nanotubes (SWCNTs). A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60. This cycloaddition and its lysine adduct provides the benefits of dense, covalent modification, ease of purification, commercial availability of… CONTINUE READING

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A 1,3-cycloaddition was developed using an azomethine ylide , generated by reacting paraformaldehyde and a side - chain - Boc ( tert - Butyloxycarbonyl)-protected , lysine - derived alpha - amino acid , H - Lys(Boc)-OH , with purified SWCNT or C60 .
A 1,3-cycloaddition was developed using an azomethine ylide , generated by reacting paraformaldehyde and a side - chain - Boc ( tert - Butyloxycarbonyl)-protected , lysine - derived alpha - amino acid , H - Lys(Boc)-OH , with purified SWCNT or C60 .
A 1,3-cycloaddition was developed using an azomethine ylide , generated by reacting paraformaldehyde and a side - chain - Boc ( tert - Butyloxycarbonyl)-protected , lysine - derived alpha - amino acid , H - Lys(Boc)-OH , with purified SWCNT or C60 .
Functionalized SWCNTs strongly wrapped small interfering RNA ( siRNA ) .
Functionalized SWCNTs strongly wrapped small interfering RNA ( siRNA ) .
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