Synthesis, optical resolution, and stereochemical properties of a rationally designed chiral C–N palladacycle

@article{Yap2014SynthesisOR,
  title={Synthesis, optical resolution, and stereochemical properties of a rationally designed chiral C–N palladacycle},
  author={Jeanette See Leng Yap and Houguang Jeremy Chen and Yongxin Li and Sumod Appukuttan Pullarkat and Pak-Hing Leung},
  journal={Organometallics},
  year={2014},
  volume={33},
  pages={930-940}
}
A novel racemic tertiary amine, 1-(2,5-diisopropylphenyl)-N,N-dimethylethanamine, was synthesized from 2,5-diisopropylbenzaldehyde via a multistep approach in high overall yield. The ortho palladation of this ligand was found to be sensitive to the reaction conditions and the palladating reagents employed. The metal complexation process could thus generate a cyclopalladated complex in high yield, lead to an unexpected N-demethylated amine palladium(II) complex, or both. Both products have been… Expand
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TLDR
The iridation of (R)-N,N-dimethyl-1-(1-naphthyl)ethylamine in the presence of a base afforded an assortment of products ranging from organic molecules to coordinated systems and cyclometalated complexes, and generated an unprecedented carbocyclic η1,η2-cycloiridated species that could not be attained from the directcyclometalation of its organic ligand. Expand

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