Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.

@article{Carroll2010SynthesisNA,
  title={Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.},
  author={F Ivy Carroll and Wei Ma and Liu Deng and Hern{\'a}n A. Navarro and Mohamad Imad Damaj and Billy R. Martin},
  journal={Journal of natural products},
  year={2010},
  volume={73 3},
  pages={306-12}
}
In 1992, John Daly et al. reported the isolation and structure determination of epibatidine. Epibatidine's unique structure and its potent nicotinic agonist activity have had a tremendous impact on nicotine receptor research. This research has led to a better understanding of the nicotinic acetylcholine receptor (nAChR) pharmacophore and to epibatidine analogues with potential as pharmacotherapies for treating various CNS disorders. In this study, we report the synthesis, receptor binding ([(3… CONTINUE READING