Synthesis, molecular structure, conformational analysis, and chemical properties of silicon-containing derivatives of quinolizidine.

@article{Lazareva2012SynthesisMS,
  title={Synthesis, molecular structure, conformational analysis, and chemical properties of silicon-containing derivatives of quinolizidine.},
  author={N. F. Lazareva and B. Shainyan and U. Schilde and N. Chipanina and L. Oznobikhina and A. I. Albanov and E. Kleinpeter},
  journal={The Journal of organic chemistry},
  year={2012},
  volume={77 5},
  pages={
          2382-8
        }
}
  • N. F. Lazareva, B. Shainyan, +4 authors E. Kleinpeter
  • Published 2012
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • A silicon analog of quinolizidine 3,3,7,7-tetramethylhexahydro-1H-[1,4,2]oxazasilino[4,5-d][1,4,2]oxazasilin-9a-yl)methanol 3 was synthesized. X-ray diffraction analysis confirmed the trans configuration and low temperature NMR spectroscopy both the flexibility (barrier of interconversion 5.8 kcal mol(-1)) and the conformational equilibrium (chair-chair and chair-twist conformers) of the compound. The relative stability of the different isomers/conformers of 3 was calculated also at the MP2/6… CONTINUE READING
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