Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives.

@article{Naim2017SynthesisMD,
  title={Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives.},
  author={Mohd Javed Naim and Md. Jahangir Alam and Farah Nawaz and V. G. M. Naidu and Shams Aaghaz and Meeta Sahu and Nadeem A. Siddiqui and Ozair Alam},
  journal={Bioorganic chemistry},
  year={2017},
  volume={73},
  pages={24-36}
}
A series of thiazolidinedione based amide derivatives were designed, synthesized and docked against the PPARγ receptor target. 11 compounds from the series with good glide scores were selected for in vivo antidiabetic study based on streptozotocin induced diabetic rat model. It was observed that 4 compounds (6c, 6e, 6m &6n) showed significantly good… CONTINUE READING