Synthesis, in vitro and in vivo evaluation of 18F-fluoronorimatinib as radiotracer for Imatinib-sensitive gastrointestinal stromal tumors.

@article{Prause2018SynthesisIV,
  title={Synthesis, in vitro and in vivo evaluation of 18F-fluoronorimatinib as radiotracer for Imatinib-sensitive gastrointestinal stromal tumors.},
  author={Martin Prause and Sabrina Niedermoser and Carmen Waengler and Clemens Decristoforo and Uwe Seibold and Stephanie Riester and T. Taguchi and Ralf Schirrmacher and Gert Fricker and Bj{\"o}rn W{\"a}ngler},
  journal={Nuclear medicine and biology},
  year={2018},
  volume={57},
  pages={1-11}
}
INTRODUCTION Gastrointestinal stromal tumors (GIST) have a wide range of mutations, but can mostly be treated with Imatinib, until eventually resistance towards this tyrosine kinase inhibitor is acquired. Early and non-invasive determination of the sensitivity of the tumor and its metastases towards Imatinib by positron emission tomography (PET) would be… CONTINUE READING