Synthesis, in vitro and in vivo evaluation of a delivery system for targeting anticancer drugs to the brain.

@article{ElSherbeny2003SynthesisIV,
  title={Synthesis, in vitro and in vivo evaluation of a delivery system for targeting anticancer drugs to the brain.},
  author={Magda A. El-Sherbeny and Huda S Al-Salem and Maha Abd-Alrahman Sultan and Mahasen Ali Radwan and Hassan Ahmed Farag and Hussein Ibrahim El-Subbagh},
  journal={Archiv der Pharmazie},
  year={2003},
  volume={336 10},
  pages={445-55}
}
A 1, 4-dihydropyridine <--> pyridinium salt type redox system is described as a general and flexible method for site-specific and sustained delivery of drugs to the brain. This concept was used in the present investigation as a model to deliver an alkylating antitumor agent into the brain. A bis-(chloroethyl)amine drug was hooked to 1, 4-dihydropyridine chemical delivery system (CDS) through an amide linkage. Five new-target compounds (23-27) of the 1, 4-dihydropyridine CDS type were… CONTINUE READING