Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones.


A 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one library was constructed and tested against the colon cancer cell line HCT-116 as an initial screen for cytotoxic properties. Of this library, the parent compound, in which the southern aromatic ring remains unsubstituted, and the northern aromatic ring carries a 4-methoxy group, exhibited the most potent… (More)


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@article{Kimball2007SynthesisIV, title={Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones.}, author={F Scott Kimball and Ashok Rao Tunoori and Samuel F Victory and Dinah Dutta and Jonathan L. White and Richard H. Himes and Gunda I. Georg}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 16}, pages={4703-7} }