Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.

@article{Desbouis2008SynthesisIV,
  title={Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.},
  author={Dominique Desbouis and Harriet S R Struthers and Vojtěch Spiwok and Tatiana K{\"u}ster and Roger Schibli},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 21},
  pages={6689-98}
}
Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for noninvasive imaging of cancer cell proliferation using radiolabeled substrates such as [ (18)F]fluorothymidine ([ (18)F]FLT). However, a thymidine tracer useful for single photon emission tomography (SPECT) based on the inexpensive radionuclide technetium-99m would be of significant interest. In this work, a series of thymidine derivatives labeled with the organometallic [M(CO) 3] (+) core (M = (99m)Tc, Re) were… CONTINUE READING