Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease.

@article{Ramajayam2010SynthesisDS,
  title={Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease.},
  author={R Ramajayam and Kian-Pin Tan and H Liu and Po-Huang Liang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 12},
  pages={3569-72}
}
A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds. 

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

References

Publications referenced by this paper.
Showing 1-2 of 2 references

General procedure for the synthesis of compound 6a–n: To a mixture of 6-aryl-5-cyano-2-thiouracil

R. Ramajayam, N. B. Mahera, +3 authors Arch. Pharm
DMF • 2009

Coronaviruses: Molecular Biology, 3rd ed

S. C. Baker
In Encyclopedia of Virology; Academic Press: New York, • 2008

Similar Papers

Loading similar papers…