Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.

@article{Jonckers2002SynthesisCA,
  title={Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.},
  author={Tim H. M. Jonckers and Sabine van Miert and Kanyanga Cimanga and Christian Bailly and Pierre Colson and Marie-Claire A De Pauw-Gillet and Hilde van den Heuvel and Magda Claeys and Filip Lemi{\`e}re and Eddy Esmans and Jef Rozenski and Ludo Quirijnen and Louis Maes and Roger Dommisse and G. L. Lemi{\'e}re and Arnold J. Vlietinck and Luc Pieters},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 16},
  pages={3497-508}
}
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid from Cryptolepis sanguinolenta, derivatives were prepared using a biradical cyclization methodology. Starting from easily accessible educts, this approach allowed the synthesis of hitherto unknown compounds with a varied substitution pattern. As a result of steric hindrance, preferential formation of the 3-substituted isomers over the 1-substituted isomers was observed when cyclizing N-(3… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
15 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…