• Corpus ID: 212514877

Synthesis, cytotoxic activity and molecular docking study of Bis-Rhodanine derivative

@inproceedings{Harshitharaj2016SynthesisCA,
  title={Synthesis, cytotoxic activity and molecular docking study of Bis-Rhodanine derivative},
  author={P. K. Harshitharaj and Rakesh Kumar and Subban Ravi},
  year={2016}
}
A bis-rhodanine was prepared from 1, 2 diaminopropane by microwave assisted synthesis and characterized by spectral data. The cytotoxic activity of the compound was studied by MTT assay. It showed a dose dependent cytotoxic activity and exhibited an IC50 value of 34.5 μg/ml against the HeLa cell lines. Molecular docking was carried out against the protein HPV 16 E2 present in HeLa cell line to study the binding capacity of the bis-rhodanine with the protein. It showed a docking score of -4.5… 
Synthesis, characterization, theoretical, molecular docking and in vitro biological activity studies of Ru(II) (η6 -p-cymene) complexes with novel aniline substituted aroyl selenoureas
TLDR
The docking results strongly support the protein binding studies of the complexes and the single-crystal XRD study showed that aroyl selenourea ligand coordinates with Ru via Se novel neutral monodentate atom.

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