Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives.

@article{Karakaya2019SynthesisCM,
  title={Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives.},
  author={G. Karakaya and Aslı T{\"u}re and A. Ercan and Selin {\"O}nc{\"u}l and M. Aytemir},
  journal={Bioorganic chemistry},
  year={2019},
  volume={88},
  pages={
          102950
        }
}
  • G. Karakaya, Aslı Türe, +2 authors M. Aytemir
  • Published 2019
  • Chemistry, Medicine
  • Bioorganic chemistry
  • Tyrosinase inhibitors have become increasingly important as whitening agents and for the treatment of pigmentary disorders. In this study, the synthesis of kojic acid derivatives having 2-substituted-3-hydroxy-6-hyroxymethyl/chloromethyl/methyl/morpholinomethylpiperidinyl- methyl/pyrrolidinylmethyl-4H-pyran-4-one structure (compounds 1-30) with inhibitory effects on tyrosinase enzyme were described. One-pot Mannich reaction was carried out by using kojic acid/chlorokojic acid/allomaltol and… CONTINUE READING
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