Synthesis, chemical characterization, computational studies and biological activity of new DNA methyltransferases (DNMTs) specific inhibitor. Epigenetic regulation as a new and potential approach to cancer therapy.

Abstract

This work deals with the synthesis, the chemical characterization of dibutyltin(IV) complex of caffeic acid (Bu2Sn(IV)HCAF, caf1) and its cytotoxic action on tumor cells. The coordination environment at the tin center was investigated by FTIR, (119)Sn{(1)H} cross polarization magic angle spinning, electrospray ionization mass spectroscopy in the solid state… (More)
DOI: 10.1016/j.jinorgbio.2015.06.001

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@article{Pellerito2015SynthesisCC, title={Synthesis, chemical characterization, computational studies and biological activity of new DNA methyltransferases (DNMTs) specific inhibitor. Epigenetic regulation as a new and potential approach to cancer therapy.}, author={Claudia Pellerito and O Morana and Francesca Ferrante and Giuseppe Calvaruso and Alison Notaro and Selenia Sabella and Tommaso Fiore}, journal={Journal of inorganic biochemistry}, year={2015}, volume={150}, pages={18-27} }