Synthesis, characterization and transfection of a novel folate-targeted multipolymeric nanoparticles for gene delivery.

@article{Nie2009SynthesisCA,
  title={Synthesis, characterization and transfection of a novel folate-targeted multipolymeric nanoparticles for gene delivery.},
  author={Yu Nie and Zhirong Zhang and Li Li and Kui Luo and Hong Ding and Zhongwei Gu},
  journal={Journal of materials science. Materials in medicine},
  year={2009},
  volume={20 9},
  pages={1849-57}
}
Novel folate-conjugated biodegradable multipolymeric nanoparticles (NPs) were constructed and evaluated for potential use in gene delivery to human cervical carcinomas Hela cells, which overexpressed folate receptors. Folate-poly(ethylene glycol)-poly(D: , L: -lactic-co-glycolic acid) (PELGA-F) was synthesized and collaborated with poly-L: -lysine (PLL) to form polymer-polycationic peptide-DNA (PPD) NPs. Fluorescein sodium and polylysine-condensed DNA (PD) were encapsulated in both PELGA… CONTINUE READING

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