Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.

@article{Zhang2004SynthesisCA,
  title={Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.},
  author={Xianzheng Zhang and Da-Qing Wu and C Chang Chu},
  journal={Biomaterials},
  year={2004},
  volume={25 17},
  pages={3793-805}
}
A method was developed to prepare thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels with an interpenetrating polymer network (IPN) structure for the purpose of improving its mechanical properties, response rate to temperature and sustained release of drugs. Although the differential scanning calorimetry data exhibited similarly lower critical solution temperature (LCST) between IPN- and non-IPN-PNIPAAm hydrogels, an increase in the glass transition temperature (Tg) of the IPNs… CONTINUE READING