Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin.

@article{Dozzo2005SynthesisCA,
  title={Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin.},
  author={Paola Dozzo and Myoung-Seo Koo and Stephanie L. Berger and Trudy M. Forte and Stephen B. Kahl},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 2},
  pages={
          357-9
        }
}
The efficacy of binary cancer therapies such as BNCT and PDT depends critically on the subcellular localization site of the sensitizer. This work presents the synthesis and plasma lipoprotein binding properties of the first reported binary conjugate of a boronated porphyrin with a peptide nuclear localization sequence. The porphyrin-NLS conjugate associates in vitro predominantly with low density lipoproteins. Such association provides a potentially selective entry pathway into malignant cells… CONTINUE READING
BETA

Topics from this paper.

Similar Papers

Loading similar papers…