Synthesis, characterization, and identification of N7-guanine adducts of isoprene monoepoxides in vitro.

Abstract

Isoprene (IP, 2-methylbuta-1,3-diene) is ubiquitous in the environment through emission by plants, combustion processes, and endogenous formation and exhalation by mammals, including humans. IP is also an industrial chemical, widely used in the manufacture of synthetic rubber and plastics. Like butadiene, IP is metabolized to reactive epoxides, which form… (More)

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